Calcium Correction for Albumin

Correct total serum calcium for hypoalbuminemia (Payne formula).

For educational and clinical reference. Not a substitute for medical judgment. See the medical disclaimer.
Corrected Calcium
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References

  1. Payne RB, Little AJ, Williams RB, Milner JR. Interpretation of serum calcium in patients with abnormal serum proteins. BMJ. 1973;4(5893):643-646.

How to use

  1. Enter total calcium and albumin.
  2. Corrected calcium appears instantly.
  3. Use direct ionized calcium when precision is critical.

Frequently asked questions

Formula?

Corrected Ca = Total Ca + 0.8 × (4 − Albumin). Reference albumin = 4 g/dL.

When to correct?

In hypoalbuminemia (cirrhosis, malnutrition, nephrotic syndrome), total calcium underestimates ionized (physiologically active) calcium. Correction is an estimate; direct ionized calcium is preferred when critical.

Normal range?

Total calcium normal range: 8.5–10.5 mg/dL.

Limitations?

The Payne correction is approximate and may be inaccurate in critical illness, end-stage renal disease, and acid–base disturbances. Ionized Ca is the gold standard.

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